Teenagers Rose and Bennett were in love, and then a car crash claimed Bennett's life. He left behind a grieving mother, father and younger brother, and Rose was left all alone. She has no family to turn to for support, so when she finds out she's pregnant, she winds up at the Brewer's door. She needs their help, and although they can't quite admit it, they each need her so they can begin to heal.
Actress Reese Holden has been offered a small fortune by a book editor if she can secure for publication the love letters that her father, a reclusive novelist, wrote to her mother, who has since passed away. Returning to Michigan, Reese finds that an ex-grad student and a would-be musician have moved in with her father, who cares more about his new friends than he does about his own health and well-being.
Matt Travis is good-looking, popular, and his school's best competitive swimmer, so everyone is shocked when he inexplicably commits suicide. As the following year unfolds, each member of his family struggles to recover from the tragedy with mixed results.
Joel Barish, heartbroken that his girlfriend underwent a procedure to erase him from her memory, decides to do the same. However, as he watches his memories of her fade away, he realises that he still loves her, and may be too late to correct his mistake.
After a terrible air disaster, survivor Max Klein emerges a changed person. Unable to connect to his former life or to wife Laura, he feels godlike and invulnerable. When psychologist Bill Perlman is unable to help Max, he has Max meet another survivor, Carla Rodrigo, who is racked with grief and guilt since her baby died in the crash which she and Max survived.
Jack Deebs is a cartoonist who is due to be released from jail. His comic book "Cool World" describes a zany world populated by "doodles" (cartoon characters) and "noids" (humanoids). What Jack didn't realize is that Cool World really does exist, and a "doodle" scientist has just perfected a machine which links Cool World with our world. Intrigued at seeing his creating come to life, Jack is nonetheless wary as he knows that not everything in Cool World is exactly friendly.
Honest and straightforward small-town Shirlee Kenyon chucks her boyfriend and heads for Chicago. Accidentally having to host a radio problem phone-in show, it is clear she is a natural and is hired on the spot. But the station insists she call herself Doctor, and as her popularity grows a local reporter starts digging for the truth. Problem is, the more he is around her the more he fancies her.
Terry Noonan returns home to New York's Hells Kitchen after a ten year absence. He soon hooks up with childhood pal Jackie who is involved in the Irish mob run by his brother Frankie. Terry also rekindles an old flame with Jackie's sister Kathleen. Soon, however, Terry is torn between his loyalty to his friends and his loyalties to others.